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MFM FELLOWSHIP FACULTY
LAWRENCE I. GROSSMAN, Ph.D

Wayne State University/Perinatology Research Branch -Lawrence I. Grossman, Ph.DTitle

  • Henry L. Brasza Professor of Molecular Medicine and Genetics, Wayne State University
  • Director, Center for Molecular Medicine and Genetics

Education and Training

  • BS in chemistry, City College of New York
  • PhD in genetics and biochemistry, Albert Einstein College of Medicine, NY
  • Postdoctoral, California Institute of Technology, Pasadena, CA

Research Accomplishments

  • Characterized major mitochondrial stress regulator MNRR1/CHCHD2
  • First isolated and characterized isoforms of cytochrome oxidase subunit 4
  • Discovered the rapid evolution in primates of many electron transport chain genes

Research Interests

  • Structure and function of mitochondrial DNA
  • Regulation of mitochondrial function
  • Role of mitochondria in inflammation and disease

Selected Publications

  • Aras S, Maroun M-C, Song Y, Bandyopadhyay S, Stark A, Yang Z-Q, Long MP, Grossman LI, Fernández-Madrid F (2019). Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis. BMC Cancer (2019) 19:411.
  • Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S (2018). J Biol Chem, 293: 6517-6529.

Courses

  • MGG 7010, Molecular Biology and Genetics
  • MGG 8770, Molecular Biology of Mitochondrial Disease