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MFM FELLOWSHIP FACULTY
SIDDHESH ARAS, MBBS Ph.D.

Wayne State University/Perinatology Research Branch - Siddhesh Aras, MBBS Ph.D.Title

  • Assistant Professor (Research), Center for Molecular Medicine and Genetics, Wayne State University School of Medicine. Full time status.

Education and Training

  • M.B.B.S, Grant Medical College, University of Mumbai, India (2001)
  • Residency, Clinical Microbiology, Grant Medical College, Sir JJ Group of Hospitals, Mumbai, India (2004)
  • Ph.D., Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, LA (2010)
  • Post-doctoral Fellow, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI (2014)

Research Accomplishments

  • Discovery of a novel mechanism of transcriptional activation by Epstein-Barr Nuclear Antigen 1.
  • Characterization of a novel HIF-independent oxygen responsive element activated under conditions of moderate experimental hypoxia.
  • Characterization of a novel cellular stress responsive protein, MNRR1 (Mitochondrial-Nuclear Retrograde Regulator 1).

Research Interests

  • Mitochondrial disease
  • Host cell bioenergetic regulation in response to viral infection
  • Role of mitochondria in neurodegeneration and cancer

Select Publications

  • Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI. MNRR1 (formerly CHCHD2) is a bi- organellar regulator of mitochondrial metabolism. Mitochondrion. 2015 Jan;20:43-51. PubMed PMID: 25315652.
  • Aras S, Singh G, Johnston K, Foster T, Aiyar A. Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009 Jun;5(6):e1000469. PubMed PMID: 19521517.
  • Aras S, Singh G, Johnston K, Foster T, Aiyar A. Zinc coordination is equired for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009 Jun;5(6):e1000469. PubMed PMID: 19521517.

Courses

  • Special topics in cancer metabolism (CB7300) – Cancer Bioenergetics