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IMPORTANT POINTS & DISCOVERIES

  • Molecular and culture-based studies in amniotic fluid during preterm labor showed that the amniotic cavity harbors DNA from a greater diversity of microbes than previously suspected, including as-yet uncultivated
  • The use of a rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery
  • Determination of the prevalence and clinical significance of amniotic fluid “sludge” in patients with preterm labor and intact membranes, and in asymptomatic high-risk patients for spontaneous preterm delivery
  • First description of the identification of a microbial biofilm in the amniotic fluid in intra-amniotic infection associated to amniotic fluid “sludge”
  • Analysis of the proteomic profiling of amniotic fluid in premature labor using two-dimensional liquid separation and mass spectrometry, as well as the use of a novel computational method to analyze mass spectrometric profiling of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection
  • Longitudinal study of angiogenic and anti-angiogenic factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small-for-gestational age neonate
  • The value of maternal plasma concentrations of angiogenic and angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia