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DIRECTOR - FELIPE VADILLO-ORTEGA, M.D., Ph.D.

Wayne State University/Perinatology Research Branch - Basic Research Director, Dr. Felipe Vadillo-OrtegaTitle

  • Professor, Wayne State University
Awards and Recognitions
  • National Prize for Clinical Research, National Institutes of Health of Mexico
  • National Prize for Biomedical Research, National Institutes of Health of Mexico
  • 2003 Latin American Prize in Human Nutrition
  • 2008 National Prize in Biology of Reproduction, National Academy of Medicine, Mexico
  • 2013 National Prize in Nutrition Research, Fundacion Mexicana para la Salud

Education and Training

  • MD:  National University of Mexico, Mexico City
  • PhD: Biochemistry, National University of Mexico, Mexico City
  • Masters: Molecular Biology, National University of Mexico
  • Fellowship:  Postdoctoral Fellow, School of Medicine, University of Pennsylvania; Postdoctoral Fellow, Oregon National Primate Research Center, Oregon Health Sciences University

Research Accomplishments

Dr. Felipe Vadillo-Ortega is a physician scientist with a Ph.D. in Biochemistry and has done seminal studies in obstetrics and maternal-fetal medicine. His work spanned from randomized clinical trials for the prevention of preeclampsia with the use of L-arginine and antioxidants to fundamental mechanisms behind rupture of the fetal membranes.  Dr. Vadillo-Ortega has developed a multidisciplinary and translational medicine approach to the study of pregnant women. He has published 160 papers on different aspects of the study of pregnancy diseases. He was a Professor at the largest and more recognized School of Medicine in Mexico, teaching basic sciences to medical students. He has mentored the thesis of 50 post-graduate students at the level of Medical Speciality, Master Degree and Ph.D. studies. Dr. Vadillo-Ortega has acted as a research official at several public and private institutions.

Project Principal or Alternate Investigator

  • R01 ES017022    O’Neill, M/Vadillo-Ortega  (PI)  12/15/09-05/31/16
    Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
  • RO1ES016932,  O’Neill,M/Vadillo-Ortega   (PI) 12/15/09-05/31/16, Air pollution, inflammation and preterm birth: a mechanistic study in Mexico City.

Research Interests

  • Preterm birth
  • Premature rupture of the membranes
  • Obesity in pregnancy
  • Metabolism and pregnancy

Section Title and Head Name

Laboratory of Translational Sciences in Perinatology

Brief Summary of Program

Perinatal Research Branch laboratory facilities are housed at the C.S. Mott Center. This core laboratory is equipped with different methodologies directed to study expression and regulation of different biomarkers involved in maternal and fetal diseases. Staff is composed by 8 scientists with different areas of expertise, including high-throughput PCR and ELISA, Multiplex, Western blot, cell culture, protein biochemistry, molecular biology, immunology, and animal work.

Objectives of Section

  • To provide technical and logistical support  for Perinatal Research Branch research goals
  • Develop new research projects in the field of Perinatal Research Branch interests
  • Support laboratory training of students and fellows participating in PRB research projects.

Research Questions

  • Mechanisms of premature rupture of the membranes
  • Normal and abnormal pregnancy metabolomic profiling
  • Inflammation and preterm labor
  • Cervicovaginal microbiome in normal and abnormal pregnancy

Important points and discoveries

The Laboratory of Translational Sciences in Perinatology conducts research with the goal of developing novel diagnostic, therapeutic and preventive strategies to reduce adverse pregnancies outcomes, infant mortality and disability.

Publications

  • Romero R, et al. Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile. Journal of Perinatal Medicine. 2016; 44(1):77-98.  https://doi-org.proxy.lib.umich.edu/10.1515/jpm-2015-0103
  • Plazyo O, et al. HMGB1 induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome. Biology of Reproduction. 2016;95(6):130,1-14.  https://doi-org.proxy.lib.umich.edu/10.1095/biolreprod.116.144139
  • Romero R, et al. Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response. Journal of Perinatal Medicine. 2016; 44(1):5-22.  https://doi-org.proxy.lib.umich.edu/10.1515/jpm-2015-0045
  • Gomez-Lopez N, et al. In vivo T-cell activation by , a monoclonal αCD3ε antibody induces preterm labor and birth. Amer J Reprod Immunol 2016; 76:386-390. DOI: 10.1111/aji.12562
  • Gomez-Lopez N, et al. Evidence for a role for the adaptative immune response in human term parturition. Am J Reprod Immunol 2013; 69:212-230. DOI: 10.1111/aji.12074

 

OFFER EREZ, MD

Wayne State University/Perinatology Research Branch - Offer Erez, MDTitle

  • Professor, Research, Department of Obstetrics and Gynecology, Wayne State University School of Medicine

Education and Training

  • M.D. – Ben Gurion University of the Negev Israel
  • Internship and Residency – Department of Obstetrics and Gynecology, Soroka University Medical Center , Ben Gurion University of the Negev, Beer Sheva, Israel
  • Research associate – Perinatology Research Branch

Research Accomplishments

  • Development of a pregnancy specific DIC scoring system
  • Study of the changes of the coagulation system in the great obstetrical syndromes
  • The use of low molecular heparins for the prevention of preeclampsia and fetal growth restriction
  • Authored and co-authored more than 180 peer reviewed publications and 10book chapters

Awards and Recognitions

  • Best Clinical Department of the Soroka University Medical Center for 2015
  • Distinguished Reviewer of Thrombosis Research 2014
  • Recognized among the Top 5% of American Journal of Obstetrics and Gynecology Reviewers in 2012
  • 2008 Perinatology Research Branch Award of Academic Excellence

Research Interests

  • Changes in the coagulation system in the great obstetrical syndromes and their use as biomarkers for these diseases.
  • Early diagnosis and treatment of maternal DIC and prevention of maternal mortality
  • The interaction between inflammation and coagulation during human pregnancy
  • Evolution of human pregnancy and parturition