COPYRIGHT 2008- WAYNE STATE UNIVERSITY

All original images / photographs in this website are copyrighted and may not be reproduced, transmitted, altered or used in any way without prior written permission from Wayne State University.

DIRECTOR - YEON MEE KIM, M.D., PH.D.

Wayne State University/Perinatology Research Branch - Director, Yeon Mee Kim, M.D., Ph.D.Title

  • Professor, Department of Pathology, Wayne State University School of Medicine
  • Director, Placental Laboratory, Perinatology Research Branch
    Full-Time Status

Education and Training

  • Inje University College of Medicine, Busan, Republic of Korea
  • Graduate School (Master of Science in Medicine), Major in Pathology, Inje University, Busan, Republic of Korea
  • Graduate School (Ph.D.), Major in Molecular Medicine, Kyungpook National University, Daegu, Republic of Korea
  • Anatomic Pathology, Sanggye Paik Hospital, Inje University, Seoul, Republic of Korea
  • Neuropathology and Pediatric Pathology, Children’s Hospital, Seoul National University, Seoul, Republic of Korea
  • Perinatology and Placenta Pathology, Perinatology Research Branch/NICHD/NIH, Detroit, Michigan, USA

Awards and Recognitions

  • Member, Korean Society of Pathology
  • Member, Korean Society of Cytopathology
  • Assistant Professor, Department of Pathology, Wayne State University, Detroit Medical center, Detroit, Michigan, USA
  • Associate Professor, Department of Pathology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea
  • Chair, Department of Pathology, Haeundae Paik Hospital, Inje University, Busan, Republic of Korea

Research Interests

  • Placental and Perinatal Pathology
  • Neuropathology

Selected Publications

  • S Hong, R Romero, D C Lee, N G Than, L Yeo, P C Chaesaithong, S Ahn, J S Kim, C J Kim, Y M Kim. Umbilical cord prostaglandins in term and preterm parturition.  Journal of Maternal-Fetal & Neonatal Medicine 2016; 29:523-31.
  • R Romero, P Chaemsaithong, N Docheva, S J Korzeniewski, J P Kusanovic, B H Yoon, JS Kim, N Chaiyasit, A I Ahmed, F Qureshi, S  Jacques, C J Kim, S S Hassan, T Chaiworapongsa, L Yeo, Y M Kim. Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity. Journal of Perinatal Medicine 2016; 44(1):33-51.
  • R Romero, P Chaemsaithong, N Docheva, S J Korzeniewski, A Tarca, G Bhatti, Z Xu, J P Kusanovic, N Chaiyasit, Z Dong, B H Yoon, S S hassan, T Chaiworapongsa, L Yeo, Y M Kim. Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response. Journal of Perinatal Medicine 2016; 44:53-76.
  • R Romero, P Chaemsaithong, N Docheva, S J Korzeniewski, J P Kusanovic, B H yoon, J S Kim, N Chaiyasit, A I Ahmed, F Qureshi, S M Jacques, C J Kim, S S hassan, T Chaiworapongsa, L Yeo, Y M Kim. Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisma and inflammation in the amniotic cavity. Journal of Perinatal Medicine 2016; 44:33-51.
  • CJ Kim, R Romero, P Chaemsaithong, N Chaiyasit, BH Yoon, YM Kim. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. American Journal of Obstetrics and Gynecology 2015; 213:S29-52.
    Kim JY, Kim YM. Acute atherosis of the uterine spiral arteries: clinicopathologic implications. J Pathol Transl Med. 2015 Nov; 49(6):462-71.
  • R Romero, J Miranda, JP Kusanovic, T Chaiworapongsa, P Chaemsaithong, A Martinez, F Gotsch, Z Dong, AI Ahmed, M Shaman, K Lannaman, BH Yoon, SS Hassan, CJ Kim, SJ Korzeniewski, L Yeo, Y M Kim. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques. Journal of Perinatal Medicine. 2015; 43: 19-36.
  • YM Kim, P Chaemsaithong, R Romero, M Shaman, CJ Kim, JS Kim, F Qureshi, SM Jacques, AI Ahmed, T Chaiworapongsa, SS Hassan, L Yeo, SJ Korz. The Frequency of Acute Atherosis in Normal Pregnancy and Preterm Labor, Preeclampsia, Small for Gestational Age, Fetal Death and Mid-trimester Spontaneous Abortion. Journal of Maternal-Fetal & Neonatal Medicine 2015; 28:2001-9.
  • YM Kim, P Chaemsaithong, R Romero, M Shaman, CJ Kim, JS Kim, F Qureshi, SM Jaques, A Ahmed, T Chaiworapongsa, S Hassan, L Yeo, SJ Korzeniewski. Placental lesions associated with acute atherosis. Journal of Maternal-Fetal & Neonatal Medicine 2015; 28:1554-62.
  • R Romero, J Miranda, P Chaemsaithong, T Chaiworapongsa, JP Kusanovic, Z Dong, AI Ahmed, M Shaman, K Lannaman, BH Yoon, S Hassan, CJ Kim, S J Korzeniewski, L Yeo, YM Kim. Sterile and Microbial-associated Intra-amniotic Inflammation in Preterm Prelabor Rupture of Membranes. Journal of Maternal-Fetal & Neonatal Medicine 2015; 28:1394-409.
  • R Romero, J Miranda1, T Chaiworapongsa1, P Chaemsaithong, F Gotsch, YM Kim. Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. Journal of Maternal-Fetal & Neonatal Medicine 2015; 28:1343-59.
  • Han Y, Romero R, Kim Y, Kim JS, Richani K, Friel L, Kusanovic J, Jeanty C, Vitale S, Nien J, Espinoza J, Kim C. Surfactant protein-A mRNA expression by human fetal membranes is increased in histological chorioamnionitis but nor in spontaneous labour at term. J Pathol. 2007; Feb 1; 211(4):489-496.
  • Richani K, Romero R, Soto E, Nien JK, Cushenberry E, Kim YM, Espinoza J, Kim CJ. Genetic origin and proportion of basal plate surface-lining cells in normal and abnormal pregnancies. Hum Pathol. 2007; 38(2): 269-75.
  • Kim JS, Romero R, Cushenberry E, Kim YM, Erez O, Nien JK, Yoon BH, Espinoza J, Kim CJ. Distribution of CD14+ and CD68+ macrophages in the placental bed and basal plate of women with preeclampsia and preterm labor. Placenta; 2007; 28(5-6): 571-6.
  • Kim YM, Romero R, Chaiworapongsa T, Espinoza J, Mor G, Kim CJ. Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes. Histopathology. 2006; Nov; 49(5): 506-14.
  • S Venkatesha, M Toporsian, C Lam, J Hanai, T Mammoto, Y M Kim, Y Bdolah, K-H Lim, H-T Yuan, T A Libermann, I E Stillmen, D Roberts, P A D’Amore, F H Epstein, F W Sellke, R Romero, V P Sukhatme, M Letarte & S Ananth Karumanchi. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nature Medicine. 2006; 12 (6):642-9.
  • Kim CJ, Kim JS, Kim YM, Cushenberry E, Richani K, Espinoza J, Romero R. Fetal macrophages are not present in the myometrium of women with labor at term. Am J Obstet Gynecol. 2006; 195(3):829-33.
  • Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim YM, Mazor M, Romero R. Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature. Am J Obstet Gynecol. 2006; 195 (2):394.e1-24.
  • Espinoza J, Romero R, Kim YM, Kusanovic JP, Hassan S, Erez O, Gotsch F, Than NG, Papp Z, Kim CJ. Normal and abnormal transformation of the spiral arteries during pregnancy. J Perinat Med. 2006; 34(6): 447-58.
  • Y.M. Kim, R. Romero, S.Y. Oh, C.J. Kim, B.A. Kilburn, D.R. Armant, J.K. Nien, R. Gomez, M. Mazor, S. Saito, V.M. Abrahams, G. Mor. Toll-like receptor 4: a potential link between "danger signals”, the innate immune system, and preeclampsia? Am J Obstet Gynecol. 2005 Sep; 193:921-7.
  • G J Kim, R Romero, H Kuivaniemi, G Tromp, R Haddad, Y M Kim, M R Kim, J K Nien, JS Hong, J Espinoza, J Santolaya, B H Yoon, M Mazor and C J Kim. Expression of bone morphogenetic protein 2 in normal spontaneous labor at term, preterm labor, and preterm premature rupture of membranes. Am J Obstet Gynecol. 2005 Sep; 193:1137-43.
  • JS. Hong, J. Santolaya-Forgas, R. Romero, J. Espinoza, L. F. Gonçalves, Y.M. Kim, S. Edwin, B.H. Yoon, J.K. Nien, S. Hassan, M. Mazor. Maternal plasma osteoprotegerin concentration in normal pregnancy. Am J Obstet Gynecol. 2005 Sep; 193(3 Pt 2):1011-5.
  • Y.M. Kim, R. Romero, T. Chaiworapongsa, G.J. Kim, M.R. Kim, H. Kuivaniemi, G. Tromp, J Espinoza, E. Bujold, R. V. Abrahams, G. Mor. Toll-like receptor-2 and –4 in the chorioamniotic membranes in spontaneous labor at term and in preterm parturition that are associated with chorioamnionitis. Am J Obstet Gynecol. 2004; 191:1346-55.
  • Abrahams VM, Bole-Aldo P, Kim YM, Straszewski-Chavez SL, Chaiworapongsa T, Romero R, Mor G. Divergent Trophoblast Responses to Bacterial Products Mediated by TLRs. J Immunol. 2004; 173(7):4286-96.
  • Abrahams VM, Kim YM, Straszewski SL, Romero R, Mor G. Macrophages and apoptotic cell clearance during pregnancy. Am J Reprod Immunol. 2004; 51:275-82.
    C.J. Kim, B.H. Yoon, J.K. Hun, J.O. Park, S.Y. Cho, R. Romero, Y.M. Kim, E.S. Yu. Promyelocytic leukaemia (PML) protein expression in human placenta and choriocarcinoma. J Pathol. 2003; 201: 83-9.
  • Y.M. Kim, E. Bujold, T. Chaiworapongsa, R. Gomez, B. H. Yoon, H. T. Thaler, S. Rotmensch, R. Romero. Failure of the physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2003; 189(4):1063-9.
  • Y.M. Kim, T. Chaiworapongsa, R. Gomez, E. Bujold, B. H. Yoon, S. Rotmensch, H. T. Thaler, R. Romero. Failure of the physiologic transformation of the spiral arteries in the placental bed in pregnancies complicated by premature rupture of membranes. Am J Obstet Gynecol. 2002; 187(5):1137-42.
  • Kim YM, J Espinoza, MR Kim, T Chaiworapongsa, E Bujold, S Berman, R Romero. The frequency of acute atherosis of the spiral arteries in the "great obstetrical syndromes". Am J Obstet Gynecol. 2002; 187: S238.
  • Romero R, Gomez R, Chaiworapongsa T, Conoscenti G, Kim JC, Kim YM. The role of infection in preterm labor and delivery. Paediatr Perinat Epidemiol. 2001; 15(2): 41-56.

Courses

  • None

FAISAL QURESHI, MD

Wayne State University/Perinatology Research Branch - Faisal Qureshi, MDTitle

  • Associate Professor of Pathology
  • Director of Obstetrical and Perinatal Pathology, Hutzel Women’s Hospital

Education and Training

  • FSc, Pre-Medicine, Government College, Lahore, Pakistan
  • M.B.; B.S., Medicine, King Edward Medical College, Lahore, Pakistan
  • Anatomic and Clinical Pathology, DePaul Hospital, Bridgeton, MO
  • Anatomic Pathology, S.U.N.Y. Buffalo, New York
  • Anatomic Pathology, Christ Hospital, Oak Lawn, IL
  • Pediatric Pathology, The Children’s Hospital, Boston, MA

Awards and Recognition

  • Nosology Subcommittee, Perinatal Division, Society for Pediatric Pathology
  • Member, P&T Committee, Department of Pathology
  • Member, Search Committee for Chairman, Department of Pathology

Research Interests

  • Placental Pathology
  • Perinatal Pathology
  • Soft Tissue and Bone Pathology

Select Publications

  • McNamara M, Wallis T, Qureshi F, Jacques SM, Gonik B.  Determining the maternal and fetal cellular immunologic contributions in preterm deliveries with clinical or subclinical chorioamnionitis.  Infect Dis Obstet Gynecol (1997)5:273-9.
  • Qureshi F, Jacques SM, Bendon RW, Faye-Peterson OM, Heifetz SA, Redline R, Sander CM.  Candida funisitis: a clinicopathologic study of 32 cases.  Pediatr Devel Pathol (1998)1:118-24.              
  • Jacques SM, Qureshi F. Chronic chorioamnionitis: A clinicopathologic and immunohistochemical study. Hum Pathol ,(1998)29:1457-1461.
  • Pacora P, Chaiworapongsa T, Maymon E, Kim YM, Gomez R, Yoon BH, Ghezzi F, Berry SM, Qureshi F, Jacques SM, Kadar N, Romero R. Funisitis and chorionic vasculitis: The histologic counterpart of the fetal inflammatory response syndrome. J Matern Fetal Med (2002)11:18-25.
  • Leach RE, Romero R, Kim YM, Chaiworapongsa T, Kilburn B, Das SK, Dey SK, Johnson A, Qureshi F, Jacques S, Armant DR. Pre-eclampsia and expression of heparin-binding EGF-like growth factor. Lancet (2002)360:1215-1219.
  • Jacques SM, Qureshi F, Johnson A, Alkatib AA, Kmak DC. Estimation of time of fetal death in the second trimester by placental histopathological examination. Pediatr Devel Pathol (2003)6:226-232.
  • Kazzi SNJ, Jacques SM, Qureshi F, Kim UO, Buhimschi IA. Tissue necrosis factor-alpha allele lymphotoxin-a+250 is associated with the presence and severity of placental inflammation among preterm births. Pediatr Res (2004)56:94-98
  • Jacques SM, Qureshi F, Kim JC, Lee JH, Giorgadze T, Mittal P, Hassan SS, Romero R. Eosinophilic/T-cell chorionic vasculitis: A clinicopathologic and immunohistochemical study of 51 cases. Pediatr Dev Pathol. (2011)14:198-205.
  • Lee JH, Romero R Dong Z, Dong Z, Xu Y, Qureshi F, Jacques SM, Yoo W, Chaiworapongsa T, Mittal P, Hassan SS, Kim CJ. Unexplained fetal death has a biological signature of maternal anti-fetal rejection: Chronic chorioamnionitis and alloimmune anti-human leukocyte antigen antibodies. Histopathol. In Press

 

SUZANNE JACQUES, MD

Wayne State University/Perinatology Research Branch - Suzanne Jacques MDTitle

  • Professor of Pathology, Wayne State University School of Medicine
  • Associate Director of Obstetric and Perinatal Pathology, Hutzel Women’s Hospital, Detroit Medical Center, Detroit, MI

Education and Training

  • Graduate: Indiana University School of Medicine, Indianapolis, IN. Degree awarded: M.D.
  • Baccalaureate: University of Notre Dame, South Bend, IN. Degree awarded: B.S.

Postgraduate Training

  • Fellowship: Obstetric/Gynecologic Pathology, Hutzel Hospital, Wayne State University School of Medicine, Detroit, MI 
  • Residency: Anatomic and Clinical Pathology, New England Deaconess Hospital, Harvard Medical School, Boston, MA
  • Residency: Anatomic and Clinical Pathology, Methodist Hospital of Indianapolis, Indianapolis, IN

Research Interests

  • Primary research interest is placental and perinatal pathology, and I have microscopically examined tens of thousands of placentas in the course of my career and participated in over 1000 fetal and neonatal autopsies at Hutzel Women’s Hospital.
  • Special interests include: 1) placental viral and bacterial infections, chronic inflammatory lesions, and placental vascular abnormalities. 2) Unexplained stillbirth, particularly in the third trimester of pregnancy, including reports of fetal neuropathologic abnormalities and their association with other autopsy findings and placental lesions, and exploration of the timing of onset of acute illness in stillbirth. 3) Case reports focusing largely on types and patterns of complex congenital anomalies identified in fetal autopsies, many of which are rare or unique.

Research Accomplishments

  • Published over 80 peer-reviewed original observations, case reports, and letters to the editor, the majority of which are in the field of perinatal pathology, including placental pathology and issues related to the fetal autopsy, as well as gynecologic pathology.
  • Primary presenter or a co-author of nearly 100 abstracts presented at national and international meetings.
  • Collaborations with many other faculty members, primarily in the Department of Pathology, Department of Obstetrics and Gynecology at Wayne State University, and Perinatal Research Branch, but also with faculty at outside institutions, including the Amsterdam Placental Pathology Group, a workshop group convened to address the need for a consensus-determined protocol for sampling the placenta and collectively agreed upon definitions of placental lesions.