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IMPORTANT POINTS & DISCOVERIES

  • Korzeniewski et al report that children exposed to transient hypothyroxinaemia of prematurity (THOP) were at increased risk of autism spectrum disorders (ASD) when born to mothers unaffected by hypertension during pregnancy. While the primary relation between THOP and ASD among all low birth weight children was not statistically significant, the magnitude of association and significant relationship observed in the subgroup whose mothers did not have hypertension during pregnancy suggest further investigation is warranted.
  • Upon performing the first prospective cohort study to examine maternal plasma concentrations of placental growth factor (PlGF), soluble endoglin (sEng), and soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) at 30-34 weeks of gestation, Chaiworapongsa et al report that risk assessment for stillbirth and severe late preeclampsia in the third trimester is possible with the determination of these factors.
  • Whitten and colleagues report that an imbalance of angiogenic/antiangiogenic factors is present in patients with Massive perivillous fibrin deposition (MPFD) prior to the diagnosis and further propose that these changes participate in the mechanisms responsible for adverse pregnancy outcomes in patients with MPFD.
  • Hernandez-Andrade and colleagues report that in patients with a cervical length of <25 mm by transvaginal ultrasound, transabdominal measurement of the cervix overestimated this parameter by an average of 8 mm (95% LOAs, -10.5 to 26.4 mm). Yet, among women without a short cervix, transabdominal ultrasound underestimated cervical length on average by 1.1 mm (95% LOAs, -13.2 to 11.0 mm). Overestimation among women with a short cervix resulted in the under-diagnosis of 57% of these cases.
  • Korzeniewski et al report that newborn screening programs that operate primary thyrotropin blood spot testing protocols and do not incorporate serial screens may fail to identify approximately half of newborns with congenital thyroid hormone deficiency that are transferred to the NICU after birth.