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IMPORTANT POINTS & DISCOVERIES

  • Development of a unique pregnant rabbit model of maternal inflammation-induced cerebral palsy in the fetus characterized by neurobehavioral assessment, PET/MRI imaging, and tissue/mRNA analysis
  • Development of dendrimer-based capture assays for the detection of cytokine levels with a 20-fold improvement in sensitivity
  • Polyamidoamine (PAMAM) dendrimers can target targeted cells associated with neuroinflammation, even upon intravenous administration
  • Systemic, post-natal administration of dendrimer-based drug delivery nanodevices can attenuate neuroinflammation and improve motor deficits in newborn rabbits kits with cerebral palsy