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  • Chief, Perinatology Research Branch
  • Head, Program for Perinatal Research and Obstetrics,
    Intramural Division, NICHD, NIH

Training and Background

  • Residency in Obstetrics and Gynecology - Yale University
  • Maternal-Fetal Medicine Fellowship - Yale University
  • Director of Perinatal Research - Yale University
  • Professor and Vice-Chairman, Wayne State University
  • Professor of Obstetrics and Gynecology, University of Michigan
  • Professor of Epidemiology and Biostatistics, Michigan State University
  • Co-author of over 900 peer-reviewed publications
  • Author of books: “Obstetrical Ultrasound” and “Perinatal Diagnosis of Congenital Anomalies”
  • Editor of books: “The Principles and Practice of Ultrasonography in Obstetrics and Gynecology” and “Preterm Labor”
  • Editor-in-Chief of the American Journal of Obstetrics and Gynecology
  • Editor of Ultrasound in Obstetrics and Gynecology
  • Recipient of numerous awards including:
    • Presidential Achievement Award (SGI)
    • Ian Donald Gold Medal (ISUOG); Stockholm, Sweden
    • Erich Saling Award (World Association of Perinatal Medicine); Osaka, Japan
    • Research Excellence Awards (SMFM, ACOG, CAOG, ISUOG)
  • Member of the Institute of Medicine of the National Academies of the United States
  • Recipient of Doctorate Honoris Causa degrees from eight universities worldwide
  • Elected Member of the Academy of Scholars, Wayne State University

Contributions and Areas of Interest

  • Early diagnosis and treatment of ectopic pregnancy:
    • -The discriminatory hCG zone
    • -Serial hCG determinations
    • -Ultrasound assessment of the pelvis
    • -Laparoscopic treatment of ectopic pregnancy
  • Prenatal diagnosis of congenital anomalies with ultrasound
    • -STIC for the diagnosis of congenital heart disease
    • -Functional evaluation of the fetal heart
  • Longitudinal studies of fetal growth
  • Three-dimensional and four-dimensional ultrasound
  • Invasive procedures for prenatal diagnosis (amniocentesis, cordocentesis, endoscopy and fetal endoscopic surgery)
  • Subclinical intrauterine infection in preterm labor and preterm PROM
  • Role of cytokines and chemokines in spontaneous labor at term and infection-induced preterm labor
  • The fetal inflammatory response syndrome (FIRS)
  • The role of the human fetus in the onset of preterm labor
  • Fetal systemic inflammation as a cause of cerebral palsy and chronic lung disease
  • Development of novel methods for the rapid diagnosis of intrauterine infection/inflammation
  • Treatment of intrauterine infection and intrauterine inflammation
  • High-dimensional biology (genomics, proteomics, metabolomics) to understand perinatal disease
  • The role of progesterone in the prevention of preterm birth