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DIRECTOR - ADI LAURENTIU TARCA, Ph.D.

Wayne State University/Perinatology Research Branch - Bioinformatics Director, Adi LaurentiuTarca, Ph.D.Title

  • Assistant Professor, Department of Computer Science & Center for Molecular Medicine and Genetics Wayne State University

Education and Training

  • B.Sc. - Chemical Engineering, "Politehnica" University, Bucharest, Romania
  • M.Sc. - Electrochemistry, National Polytechnic Institute of Grenoble, France
  • Ph.D. - Chemical Engineering, Laval University, Quebec, Canada
  • Postdoctoral training - Bioinformatics, Center for Research in Forest Biology & CHUL Research Center, Laval University, Quebec, Canada

Research Accomplishments

  • Neural networks and genetic algorithms applied to engineering problems
  • Development of a software package for microarray data normalization (nnNorm) and a package for the analysis of signaling pathways (SPIA) based on microarray data
  • Tutorial in “machine learning” in PLoS Computational Biology

Awards and Recognitions

  • Funding NSERC (Canada) for Ph.D., Laval University, 2001 - 2003
  • Scholarship CNRS (France) for M.Sc., I.N.P. Grenoble, 2000
  • Scholarship TEMPUS (European Community) for M.Sc., I.N.P. Grenoble, 1999 - 2000
  • Scholarship TEMPUS for internship, U.S.T. Lille, 1997
  • Scholarship for Performance, U.P. Bucharest, 1998 - 1999

Research Interests

  • Microarray data pre-processing
  • Machine learning
  • Neural networks
  • Bioinformatics
  • Genetic algorithms

SORIN DRAGHICI, Ph.D.

Wayne State University/Perinatology Research Branch - Bioinformatics Faculty - Sorin Draghici, Ph.D.Title

  • Professor, Wayne State University
    Department of Computer Science, joint with Department of Obstetrics and Gynecology

Education and Training

  • B.Sc. - Computer Science, Politehnica University, Bucharest, Romania
  • M.Sc. - Computer Science, Politehnica University, Bucharest, Romania
  • Ph.D. - Computer Science, University of St. Andrews, St. Andrews, Scotland

Research Accomplishments

  • Author of the book "Statistics and Data Analysis for Microarrays using R and Bioconductor". Chapman and Hall/CRC Press, 2012.
  • Author of the book "Data Analysis Tools for DNA Microarrays". Chapman and Hall/CRC Press, 2003 (first print), 2006 (second revised print).
  • Editor, IEEE Transactions on Computational Biology and Bioinformatics
  • Editor, Journal of Biomedicine and Biotechnology

Awards and Recognitions

  • Numerous awards from prestigious institutions, including:
    • National Science Foundation
    • National Institute of Health
    • Department of Defense - U.S. Army Medical Research and Material Command
    • Michigan Life Science Corridor
    • Sun Microsystems
    • Open Channel Software
    • Children's Hospital of Michigan
    • Center for Molecular Medicine and Genetics, Wayne State University
    • Michigan Space Grant Consortium
  • Outstanding Faculty Service Award, College of Engineering, Wayne State University, Detroit, MI, USA, 2012
  • Appointed as the Robert J. Sokol, MD, Endowed Chair in Systems Biology, July 2011
  • Joint appointment as Professor in the Department of Clinical and Translational Science, July 2011
  • Joint appointment as Professor in the Department of Obstetrics and Gynecology, July 2011
  • ISI/Thompson Scientific Fast Breaking Paper Award in Computer Science, Oct 2006
    According to ISI Thompson Scientific, these papers comprise the top 1% of (journal) papers in each field and each year
    http://www.esi-topics.com/fbp/fbp-october2006.html
  • Elevated at the level of Senior Member in IEEE, 2005 (fewer than 1% of IEEE members are Senior Members)
  • Pass et. al, 2004 was featured on the cover of the February 2004 issue of Clinical Cancer Research
  • Draghici et. al, 1997 was featured on the cover of the Proc. of Artificial Neural Networks in Engineering 1997, published as a book by ASME Press, ISBN 0-7918-0064-4
  • Wayne State University College of Science Teaching Award, 2000
  • British Council Overseas Research Award, 1991
  • University of St. Andrews Research Award, 1990

Research Interests

  • Analysis techniques for biological pathways
  • Functional analysis of high throughput data
  • Machine learning, neural networks and their applications to bioinformatics
  • Data mining in bioinformatics databases
  • Normalization and pre-processing methods for microarray data
  • Novel methods of selection of differentially regulated genes
  • Methods for the assessment of cluster confidence of microarray data